GLP-1 Agonists

GLP-1 agonists are medications that help lower blood sugar levels and promote weight loss. Although these medications can lead to significant weight loss but unfortunately, the patients tend to gain weight back as soon they stop using medications. Obesity is complex condition that needs multiple approaches such as diet modifications, exercise and behavior modification programs

Commonly prescribed GLP-1 agonist medications used for weight loss include Liraglutide and Semaglutide (Ozympic). Tirazeptide ( Mounjaro), a GLP-1/GIP agonist, is a powerful weight loss medication that is not FDA approved yet.

ozempic, semaglutide
weight loss

How do GLP-1 agonists help with weight loss?

Semaglutide like medications work by mimicking naturally present GLP1 hormone

GLP-1 is produced in small intestine. Weight loss effect is attributed to following:

  • Slowing stomach emptying
  • Increasing how full you feel after eating

Risks / Benefits

What are the potential benefits of GLP-1 agonists?

Other than lowering blood sugar levels and reducing weight, studies show that GLP-1 agonists may have other potential benefits, like:

What are the side effects of GLP-1 agonists?

The most common side effects of GLP-1 agonists include:

Other side effects can include:

You may also have temporary mild itchiness and/or redness on your skin at the site of the injections.

Severe — but rare — side effects can include:

Contraindication

● A personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

● A prior serious hypersensitivity reaction to semaglutide or to any of the excipients in Ozempic or Wegovy. Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with semaglutide.

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